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(A) ICV leptin (5 ng/h) increased HCA during weeks 1 (*p≤0.05) and 2 in obob mice. (**p≤0.01) (B) Temporal data showing that ICV leptin produced significant (p≤0.05) increases in HCA between days 1 and 4 whereas body weight did not decrease significantly during this time (PBS group n = 3; leptin group n = 4).
