Figure 6.

Effects of chronic leptin administration on BPs in 12-week-old male Ay/+ mice during a 10-day caloric restriction. (a) Time course of body weights of Ay/+ mice treated with leptin or vehicle. (b) Time course of plasma leptin concentrations in Ay/+ mice treated with leptin or vehicle. (c) Time course of systolic BPs in Ay/+ mice treated with leptin or vehicle. The Ay/+ mice treated with leptin or vehicle are indicated by filled and open circles, respectively. AP < 0.05, BP < 0.001 versus vehicle-treated groups assessed by ANOVA with repeated measures analysis with Student’s t test at a given time.