Table 1.

Omnibus tests of association for exposures and unsupervised RPMM CpG class methylation

		Omnibus p value
		Spearman correlation		Multivariable regression
Exposure		Supremum	1st Difference	Supremum	1st Difference
Age (years)a		<0.001	0.007	<0.001	0.006
Female genderb		0.04	0.20	0.23	0.64
Cigarette smoking
	Ever-smokingc	0.06	0.07	0.29	0.28
	Pack-yearsc,d	0.006	0.004	0.41	0.06
Alcohol consumptionc,e
	Non-drinker (reference)	-	-	-	-
	≤6.5 drinks/week	0.29	0.66	0.49	0.60
	≥6.5 drinks/week	0.34	0.42	0.47	0.60
Hair dye-usec		0.01	0.003	0.06	0.006
Arsenic (µg/g)c,f		0.31	0.26	0.17	0.06
Selenium (µg/g)c,f		0.63	0.52	0.59	0.43
Ultraviolet radiation exposure
	Tanning lamp usec	0.02	0.14	0.11	0.37
	Lifetime painful sunburnsc	0.89	0.88	0.67	0.65

Note: Supremum test = test based on the maximum absolute value. 1^st-difference test = test for structural relationships based on maximum absolute 1^st difference.

^aThe multiple regression model was adjusted for gender.

^bThe multiple regression model was adjusted for age and hair dye use.

^cThe multiple regression model was adjusted for age and gender.

^dRestricted to ever-smokers.

^eMedian = 6.5 alcoholic drinks per week among drinkers.

^fMeasured in toenail clippings.