Table 3.

^*Adjusted H19 and IGF2 DMR methylation differences between offspring exposed and those not exposed to folic acid before and during pregnancy, stratified by sex and race

	Methylation % difference for FA intake before pregnancy (n = 428)				Methylation % difference for FA intake during pregnancy (n = 223)
	IGF2 DMR		H19 DMR		IGF2 DMR		H19 DMR
Folic acid intake	Difference	p value	Difference	p value	Difference	p value	Difference	p value
All participants
Moderate	+0.28	0.76	−1.96	0.03*	0.75	0.59	−2.87	0.02*
High	−1.15	0.39	−2.76	0.04*	0.25	0.93	−4.90	0.05
Males
Moderate	−0.11	0.92	−3.08	0.01*	−1.28	0.47	−3.69	0.06
High	−1.40	0.44	−2.36	0.24	−1.69	0.57	−4.63	0.16
Females
Moderate	+0.22	0.89	−0.66	0.62	+1.92	0.46	−3.27	0.09
High	−1.90	0.37	−3.43	0.08	+6.38	0.36	−2.59	0.56
Black
Moderate	−1.18	0.44	−1.91	0.13	1.96	0.32	−2.49	0.11
High	−0.45	0.85	−3.18	0.12	−0.67	0.89	−3.66	0.53
White
Moderate	1.33	0.24	−1.80	0.20	−1.26	0.49	−4.43	0.09
High	−1.85	0.23	−2.42	0.23	−0.71	0.79	−8.37	0.24

^*Statistically significant difference among methylation percent of infants born to non-FA users and users moderate and high doses of FA.

**Referents are non-folic acid users, adjusted for maternal educational attained, race, mode of delivery and cigarette smoking. All participants are additionally adjusted for sex.