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. 2011 Aug 10;6(8):e23365. doi: 10.1371/journal.pone.0023365

Figure 5. n-3 PUFA-depleted mice exhibited hepatic insulin resistance.

Figure 5

Insulinemia (A) and glycemia (B) in fasted mice fed a control (CT; n = 6) or n-3 PUFA-depleted (DEF; n = 7) diet for 3 months. Hepatic glucose production (C) and glucose infusion rate (D) were measured during steady-state euglycemic-hyperinsulinemic clamp performed on fasted mice fed a control (CT; n = 4) or n-3 PUFA depleted (DEF; n = 6) diet for 3 months. Data are the mean ± SEM. *: mean values significantly different (P<0.05, Student's t-test).