Table 1. Heme biosynthesis enzyme presence in the endosymbiotic bacteria and the Kinetoplastida analyzed in this work.

	gltX	hemA	GSA	ALAD	PBGD	UROS	UROD	CPOX1	hemN1	PPOX2	FeCH
C. K. blastocrithidii	+	+	+	+	+	+	+	-	+	-	+
C. K. crithidii	+	+	+	+	+	+	+	+	+	+	+
C. K. galatii	+	+	+	+	+	+	+	-	+	-	+
C. K. oncopeltii	+	+	+	+	+	+	+	-	+	-	+
Angomonas deanei 3	+	-	-	-	-	-	-	+	-	+	+
Strigomonas culicis 3	+	-	-	-	-	-	-	+	-	+	+
S. galati 3	+	-	-	-	-	-	-	+	-	+	+
S. oncopelti 3	+	-	-	-	-	-	-	+	-	+	+
Crithidia acanthocephali 4	+	-	-	-	-	-	-	+	-	+	+
C. fasciculata 4	+	-	-	-	-	-	-	+	-	+	+
Endotrypanum schaudinni 4	+	-	-	-	-	-	-	+	-	+	+
Leptomonas costaricensis 4	+	-	-	-	-	-	-	+	-	+	+
Herpetomonas muscarum 4	+	-	-	-	-	-	-	-	-	-	+
Phytomonas sp. 4	+	-	-	-	-	-	-	-	-	-	+
Parabodo caudatus 5	+	-	-	-	-	-	-	-	-	-	+

Enzyme name abbreviations are as in Figure 1. 1: enzymes capable of performing the same enzymatic reaction step in the pathway. 2: the PPOX putatively identified in C. K. crithidii is of a different family from the ones identified in the Kinetoplastida (see text); 3: symbiont-harboring trypanosomatids; 4: regular trypanosomatids; 5: bodonid.