Table 1. Distribution of hydrogen bonds between Pt-amines and adjacent bases observed in MD simulations.
| TGGT | |||
| CP | OXa | ||
| Hydrogen bond type | Frequency | Hydrogen bond type | Frequency |
| G7-O6 | 20% | G7-O6 | 59% |
| T8-O4 | 37% | T8-O4 | 6% |
| T8-O4+G7-O6 | 12% | T8-O4+G7-O6 | 13% |
| None | 29% | None | 20% |
a
Only the equatorial hydrogen of the OX-amine was involved in hydrogen bonding on the 3′ side of the adduct.
b
from (Sharma et al., 2007[52]).
c
Both equatorial and axial hydrogens of the OX-amine were involved in hydrogen bonds on the 5′ side, and only equatorial hydrogen of the OX-amine was involved in hydrogen bonding on the 3′ side of the adduct.