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. 2011 Aug 10;6(8):e23560. doi: 10.1371/journal.pone.0023560

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This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Groups of 12 hamsters were infected with a lethal dose of Andes virus and treated by daily intraperitoneal injections of 0, 5, 25, 50 or 100 mg ribavirin kg⁻¹ day⁻¹ from day 1 through day 10 post-infection. For each group, 6 hamsters were monitored for survival (A), while 3 hamsters per group were euthanized on days 6 and 8 post-infection and samples collected for virological analysis (B–C). Andes virus RNA profiles were determined in lung and liver (B) and blood (C) samples collected from hamsters as noted above. The data represents the average values obtained from triplicate analysis of tissue samples collected from three hamsters per treatment group, per time point. Error bars represent the standard error of the mean.