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. 2010 Dec 23;18(4):326–333. doi: 10.1038/gt.2010.133

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Copyright © 2011 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Efficient protein down-modulation by LNA–ONs. (a) 15PC3 cells were treated with 1 or 5 μ EZN-3920 and analyzed for HER3 protein levels by immunoblotting on day 1 or day 5. β-catenin and tubulin were also analyzed for specificity. (b) 15PC3 cells were treated with indicated concentrations of EZN-4516. HSP27 protein levels were analyzed on day 1, 3 or 5. HER3 and β-tubulin proteins were also probed to indicate specificity. (c) 15PC3 cells were treated with indicated concentrations of EZN-4150 for 6 days. PIK3CA, p-AKT, AKT and HSP27 proteins were analyzed by immunoblotting. (d) SW480 cells were treated with indicated concentrations of EZN-3889 (duplicates) for 6 days and analyzed for β-catenin or β-tubulin protein levels by immunoblotting.