Table 1.
Clinical Characteristics of Patients and NSCLC tumors
| Discovery SHC Cohort | IOWA NSCLC Brain | Validation SHC Cohort | ||
|---|---|---|---|---|
| BM+ | BM− | Metastasis Tumor TissueX | ||
| No. of cases | 7 | 6 | 24 | 15 |
| Median Age years (range) | 58 (53–74) | 66.5 (60–71) | 60.5 (38–77) | 65 (46–78) |
| Gender | ||||
| Male | 1/7 (14.3%) | 3/6 (50%) | 13/24 (54.2%) | 5/15 (33.3%) |
| Female | 6/7 (85.7%) | 3/6 (50%) | 11/24(45.8%) | 10/15 (66.7%) |
| Stage at Diagnosis | ||||
| 1A or 1B | - | 2/6 (33%) | - | 4/15 (27%) |
| 2A or 2B | - | - | - | 11/15 (73%) |
| 3A or 3B | 4/7 (57.1%) | 1/6 (17%) | - | - |
| 4 | 3/7 (42.9%) | 3/6 (50%) | - | - |
| Histology | ||||
| Adenocarcinoma | 4/7 (57.1%) | 4/6 (66.6%) | 14/24 (58.4%) | 9/15 (60%) |
| Squamous cell carcinoma | 3/7 (42.9%) | 2/6 (33.3%) | 5/24 (20.8%) | 3/15 (20%) |
| NSCLC NOS#/Other | - | - | 5/24 (20.8%) | 3/15 (20%) |
X
“Stage at Diagnosis” information not available
#
Not otherwise specified or other histology is defined as neither adenocarcinoma nor squamous carcinoma or poorly differentiated and additional classification by pathologist was not available.