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Deficiency of insulin secretion caused by STZ leads to decreased expression of the glucose transporter 4 (Glut4) gene. Expression of the Glut4 gene in the gastrocnemius of the mice described in Fig. 1 was detected by immunoblotting and quantified. Results represent means ± SE (ND, n = 5; HFD, n = 5; STZ-HFD, n = 10). Veh: saline. P < 0.05, ND compared with HFD plus STZ.
