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. 2011 May 17;301(2):E370–E379. doi: 10.1152/ajpendo.00130.2011

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Fig. 4. — Effects of forskolin on cyclic nucleotide production and Ca²⁺ influx in unidentified single anterior pituitary cells from PKA mice models. A, top: basal and forskolin (5 μM)-stimulated cAMP intracellular accumulation (right) and release (left) in pituitary cells from normal (open bars), Prkar1a^+/−Prkaca^+/− (gray bars), and Prkar1a^+/− mice (black bars); means ± SE from 6 determinations. *Significant differences between normal and Prkar1a^+/− cells. A, bottom: Western blot analysis of adenylyl cyclase (AC)5/6 expression in mouse and rat pituitary cells. B: forskolin stimulates Ca²⁺ influx in anterior pituitary cells from Prkar1a^+/−Prkaca^+/− but not Prkar1a^+/− animals. Traces shown are representative of 5 similar experiments with ≥10 recordings/experiment.