Fig. 8.

[Ca²⁺]_o-mediated Ca²⁺ entry is likely through receptor-operated Ca²⁺ channels in HASMC. A: time course of [Ca²⁺]_cyt changes in HASMC induced by different concentrations of [Ca²⁺]_o in control cells. B–D: time course of [Ca²⁺]_cyt changes in HASMC induced by different concentrations of [Ca²⁺]_o in the presence of La³⁺ (10 μM), SKF-96365 (50 μM), or 2-aminoethoxydiphenyl borate (2-APB; 100 μM). E and F: summary data showing effect of La³⁺, SKF-96365, or 2-APB [Ca²⁺]_o-induced increase in [Ca²⁺]_cyt. Data are shown as means ± SE of 40–50 cells for each group. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the control in the absence of inhibitors.