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Tissue ET levels in E12.5 embryos. Combined level of mature ET-1/ET-2 is measured in wild-type (n = 8), ECE-1–/– (n = 5), ECE-2–/– (n = 7), and ECE-1–/–; ECE-2–/– (n = 7) embryos. Values are means ± SD. Statistical analysis by unpaired Student’s t test. AP < 0.05 vs. wild-type. NS, not significant.
