Table I.
Summary of results of study 1: prophylactic efficacy of hyperimmune bovine colostrum powder (400 mg doses) and placebo against infection with enterotoxigenic E. coli strain, H10407
| Treatment group | |||
|---|---|---|---|
| Placebo | Colostrum | p* | |
| Number of volunteers | 15 | 15 | |
| Number of volunteers with diarrhea | 11 (73%) | 1 1(73%) | 0.0005 |
| Number of diarrheal stools/volunteer (mean ± SEM) | 4.4 ± 0.9 | 0.4 ± 0.4 | 0.0004 |
| Mean number of diarrheal stools per volunteer with diarrhea (mean and range) | 6 (2–8) | 6(6) | NS |
| Abdominal pain | 5 (33%) | 0 (0%) | 0.04 |
| ETEC H10407 isolated from feces after challenge | 15 (100%) | 12 (80%) | NS |
*
Fisher's exact test or Student's t-test (two-tailed) as appropriate. NS, not significant.