Table II.
Summary of results of study 2: prophylactic efficacy of different doses of hyperimmune bovine colostrum powder with or without sodium bicarbonate buffer against infection with enterotoxigenic E. coli strain, H10407
| Treatment group | ||||
|---|---|---|---|---|
| Group 1: Placebo tid | Group 2: Colostrum 400 mg tid + buffer | Group 3: Colostrum 200 mg tid | Group 4: Colostrum 400 mg tid | |
| Number of volunteers | 14 | 14 | 14 | 15 |
| Number of volunteers with diarrhea | 12 (86%) | 2 (14%), p = 0.0004* | 5 (36%), p = 0.02 | 3 (20%), p = 0.007 |
| Number of diarrheal stools/volunteer (mean ± SEM) | 3.9 ± 0.8 | 0.5 ± 0.3, p = 0.0005 | 1.8 ± 0.8, p = 0.07 | 0.9 ± 0.5, p = 0.003 |
| Mean number of diarrheal stools per volunteer with diarrhea (mean and range) | 5 (3-10) | 3.5 (3-4) | 5 (2-7) | 4.7 (2-7) |
| Abdominal pain | 5 (36%) | 0 (0%), p = 0.04 | 2 (14%), p = 0.04 | 0 (0%), p = 0.02 |
| ETEC H10407 isolated from feces after challenge | 12 (86%) | 14 (100%) | 14 (100%) | 12 (80%) |
*
All tests of significance compared the results of active treatment with the placebo group and were calculated by using Fisher's exact test or Student's t-test (two-tailed) as appropriate.