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Reduction of AKT phosphorylation in urothelium of urinary bladder by intravesical deguelin (1.0 μg/10 μl) infusion. Percent pAKT-IR above threshold in the urothelium significantly (*P ≤ 0.05) decreased following intravesical instillation of deguelin (B) compared with vehicle (DMSO) treatment (A) in CYP (48 h)-treated rats. pAKT-IR was quantified as described in methods and Fig. 2. Values are means ± SE. (n = 4/group). Calibration bar = 50 μm.
