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Maximum transport rate (Jmax) and Michaelis constant (Kt) of the human, mouse and rabbit orthologs of OAT1 and OAT3 for PAH and ES, respectively
| PAH |
ES |
||||
|---|---|---|---|---|---|
| Jmax, pmol × cm−2 × min−1 | Kt, μM | Jmax, pmol × cm−2 × min−1 | Kt, μM | ||
| hOAT1 | 19.7 ± 4.08 | 11.1 ± 1.65 | hOAT3 | 5.1 ± 12.72 | 4.2 ± 0.73 |
| mOAT1 | 8.1 ± 0.72 | 5.8 ± 0.81 | mOAT3 | 55.0 ± 9.19 | 9.9 ± 1.52 |
| rbOAT1 | 10.0 ± 2.97 | 29.7 ± 5.23 | rbOAT3 | 76.1 ± 34.0 | 3.1 ± 1.65 |
Values are means ± SE of 3–4 separate experiments.
