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Grb2 and c-Cbl regulate colon epithelial cell migration. MCE cells expressing wt EGFR were transfected with NT siRNA (si) or siRNA directed against Grb2 or c-Cbl. A: knockdown of Cbl and Grb2 was determined by Western blot analysis. Blots are representative of 3 independent experiments. Transfected cells were subjected to assays for chemotactic migration (A) and restitution/wound healing migration (B). *P < 0.05 vs. NT control. n.s., Not significant.
