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Model of ErbB4 transactivation by TNF in colonic epithelial cells TNF stimulation of colonic epithelial cells leads to activation of ERK1/2, which stimulates TACE activity. TACE cleaves membrane-bound HB-EGF, which then binds to ErbB4 and stimulates phosphorylation and activation. ErbB4 transactivation by TNF then mediates colonic epithelial cell survival through increased Akt signaling.
