Table 1.
Hormone Plasma Level, pg/ml |
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GLP-1 |
PYY |
PP |
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Time point, h | Sham | Surgery | Sham | Surgery | Sham | Surgery |
0 | 39.6 ± 3.4 | 42.3 ± 3.5 | 75.0 ± 7.4 | 78.1 ± 13.5 | 66.0 ± 9.7 | 80.0 ± 10.5 |
2 | 37.6 ± 2.6 | 36.8 ± 3.7 | 65.0 ± 7.0 | 41.9 ± 3.6* | 55.5 ± 8.4 | 50.4 ± 7.6 |
5 | 37.4 ± 4.9 | 39.9 ± 2.5 | 73.4 ± 13.8 | 51.8 ± 4.6 | 64.2 ± 11.4 | 97.3 ± 8.1* |
24 | 37.2 ± 5.3 | 27.8 ± 1.8 | 110.4 ± 45.2 | 113.2 ± 26.1 | 105.1 ± 10.2 | 100.9 ± 18.2 |
Rats were fasted overnight and underwent abdominal surgery consisting of laparotomy and cecal palpation (1 min) or anesthesia alone (sham) and levels of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and pancreatic polypeptide (PP) were assessed before, and at 2, 5, 7, and 24 h postsurgery. Data are presented as means ± SE of 5 rats/group;
P < 0.05 vs. sham.