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. 2011 May 12;301(2):G287–G296. doi: 10.1152/ajpgi.00415.2010

Fig. 1.

Fig. 1.

Spontaneous transient inward currents (STICs) recorded in colonic smooth muscle cell (SMC). A and B: under voltage clamp at a holding potential of −80 mV, ongoing inward currents were recorded in human and monkey colonic SMC. This activity was divided into two components: holding current (HC, red-dotted line, A and B) and STICs (green-dotted arrow and asterisk, A and B). Aa: HC that was the measured current (red arrow) between 0 pA and the red-dotted line as an average over a 60-s recording. STICs were measured by taking an average of peak currents (green asterisk, Aa) over a period of 60 s from the red-dotted line (which represents 0 mV for measuring STIC currents). HC and STICs were collectively termed basally activated nonselective cation currents or bINSCC. r denotes single-ramp depolarization from −80 to +80 mV. B: bINSCC were also recorded in monkey colonic SMC. Ca and Da: representative traces illustrating differences in HC and STIC activity at different potentials when ECl was set to −40 mV. Cb–Cc and Db–Dc: current-voltage (I-V) relationships showing average HC and STIC activity at different potentials and this activity reversed at ∼0 mV.