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. 2011 May 12;301(2):G287–G296. doi: 10.1152/ajpgi.00415.2010

Fig. 2.

Fig. 2.

Na+ contributed to bINSCC. A and B: under voltage clamp, replacement of external Na+ (135 mM) with equimolar tetraethylammonium (TEA) significantly reduced HC and STIC activity in human and monkey colonic SMC. C: summary of the effect of TEA on HC in colonic SMC (human, n = 5; monkey, n = 6). D: summary of the effect of TEA on STICs in colonic SMC (human, n = 5; monkey, n = 5). E and F: similar effect on HC and STIC was seen with replacement of external Na+ (135 mM) with equimolar N-methyl-d-glucamine (NMDG) in human and monkey colonic SMC. G: summary of the effect of NMDG on HC in colonic SMC (human, n = 4; monkey, n = 4). H: summary of the effect of NMDG on STICs in colonic SMC (human, n = 4; monkey, n = 4). *P < 0.05 and ***P < 0.001.