Skip to main content
. 2011 May 12;301(2):G287–G296. doi: 10.1152/ajpgi.00415.2010

Fig. 4.

Fig. 4.

NSCC blockers inhibited bINSCC and influenced membrane potential. A and B: addition of the NSCC blocker, La3+ (10 μM), significantly decreased HC and STICs in human and monkey colonic SMC. C and D: Gd3+ also significantly decreased HC and STIC in human and monkey colonic SMC. E: summary of the effects of La3+ and Gd3+ on HC in colonic SMC (La3+ human, n = 5; La3+ monkey, n = 4; Gd3+ human, n = 4; Gd3+ monkey, n = 7). F: summary of the effect of La3+ and Gd3+ on STICs in colonic SMC (La3+ human, n = 5; La3+ monkey, n = 4; Gd3+ human, n = 4; Gd3+ monkey, n = 6). *P < 0.05 and ***P < 0.001. G: in current clamp (I = 0), application of the NSCC blocker, La3+ (10 μM), induced hyperpolarization in human colonic SMC (n = 4, P < 0.05). H: in monkey colonic SMC, Gd3+ (10 μM) induced membrane hyperpolarization (n = 4, P < 0.01).