Fig. 5.
The effects of divalent cations and transient receptor potential (TRP)M4 blocker on bINSCC. A and B: under voltage clamp, replacement of external Ca physiological salt solution (CaPSS) with MnPSS significantly reduced HC and STIC activity in human and monkey colonic SMC. C: summary of the effect of MnPSS on HC in human and monkey SMC (human, n = 4; monkey, n = 7). D: summary of the effect of MnPSS on STICs in human and monkey SMC (human, n = 4; monkey, n = 4). E: replacement of CaPSS with BaPSS had no effect on bINSCC in monkey SMC. F: representative trace illustrating that the TRPM4 blocker, 9-phenanthrol (100 μM), significantly reduced bINSCC in monkey colonic SMC (n = 4). *P < 0.05 and ***P < 0.001.