Fig. 7.

Single-channel conductances recorded in monkey colonic SMC. A–C: using the inside-out configuration with symmetrical Cs⁺ (140 mM), 3 conductances were recorded in monkey colonic SMC. A: at a holding potential of −60 mV, single-channel openings were recorded that were −1.5 pA in amplitude (see all-points amplitude histogram, middle). A conductance of 25 pS was calculated by plotting peak channel amplitude at different voltages and fit with linear regression (top, right) (n = 12 of 68 patches). B: at a holding potential of −80 mV, single-channel openings were recorded that had an amplitude of −0.6 pA (middle). The calculated single conductance was 5 pS (right) (n = 19 of 68 patches). C: small-conductance single-channel activity revealed noisy-like openings. Bottom: expanded time scale from box in top (n = 65 of 68 patches).