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. 2011 May 13;301(2):L161–L170. doi: 10.1152/ajplung.00073.2011

Fig. 3.

Fig. 3.

A: lung PDE2A and inducible nitric oxide synthase (iNOS) expression by Western blot with densitometric analysis measured after the following conditions in in vivo mice: IT water diluent and spontaneous ventilation, IT LPS and spontaneous ventilation, IT water followed by high tidal volume (HVT) ventilation or IT LPS followed by HVT ventilation (n = 3). All lungs were harvested 24 h after IT treatment; HVT ventilation occurred during the final 4 h of this period. Values are means ± SE. *P < 0.001 vs. all other treatment groups. B: effect of IT LPS, HVT ventilation (following IT water), or the combination on BAL cell count, LDH activity, and protein concentration (n = 3 per group). All values are expressed as fold change from an IT water-alone group (n = 2 per group). All BAL samples obtained 24 h after IT LPS or immediately after HVT ventilation which occurred during the final 4 h of this period. Values are means ± SE. *P < 0.0005 vs. all other treatment groups. #P < 0.0005 vs. HVT ventilation.