Fig. 6.
Effect of PDE2A knockdown with Ad.PDE2A-shRNA infection (n = 6) vs. control infection with Ad.Neg-shRNA (n = 7) in mice subjected to 1 day of LPS followed by HVT ventilation on BAL total cell count (A), BAL LDH concentration (B), and BAL protein concentration (C). The effects of HVT ventilation 1 day after IT LPS in the absence of adenoviral infection are also shown (n = 3) along with the effects of IT water without HVT ventilation (n = 2). LDH is shown normalized to the IT water control group. Values are means ± SE. *P < 0.05 vs. Ad.Neg-shRNA group.