Fig. 2.
Effects of liquid volume secretion rates on solids mass and water mass secretion rates in pig bronchi. A: secretion rates of solids mass (mg) plotted against liquid volume (μl) secretion rates. Relationship is linear, with slope = 0.013247, y-intercept = 0.107243, and correlation coefficient (r) = 0.917003. Slope of regression line is significantly different from zero (P < 0.05). B: secretion rates of water mass (mg) plotted against liquid secretion rates. Strongly linear relationship has slope = 0.986874, y-intercept = −0.109216, and r = 0.999980. Slope of regression line is significantly different from zero (P < 0.05). C: solids mass secretion rate is not a function of secretagogue concentration in pig bronchi. All bronchi were exposed to 10 μM ACh. Liquid secretion rate was varied by application of bumetanide and DMA to specifically inhibit Cl− and HCO3− secretion, respectively. Solids mass secretion rate was positively correlated to liquid volume secretion rate, despite a uniform concentration of ACh. Slope = 0.014109 and y-intercept = 0.083465, which closely match values obtained for aggregate data (A). Correlation coefficient (r) = 0.926874, and slope of data is significantly different (P < 0.05) from zero. D: model line prediction of percent solids from rates of liquid volume secretion in pig bronchi. Aggregate data points from Fig. 1E are shown. Model line is drawn from relationship between rates of solids mass and water mass secretion described by Eq. 5.