Fig. 3.
Evaluation of lung architecture and function after intrapulmonary injection of C/EBPα siRNA into neonatal lung exposed to 72 h of hyperoxia (O2). A: Western blots of C/EBPα protein levels (left) and densitometric evaluation of 42-kDa C/EBPα protein (right) after hyperoxic exposure preceded by injection of nonspecific (Control) or C/EBPα siRNA. Blots represent results from 3 experiments. Values are means ± SE of 4 mice in each group. *P < 0.05 vs. nonspecific. B: hematoxylin-eosin-stained lung sections obtained from A. C: radial alveolar counts (RACs) in lungs of pups obtained from A. Values are means ± SE of 3–5 mice in each group. *P < 0.01 vs. Control in Air.