Fig. 4.
mRNA levels of thyroid transcription factor 1 (TTF1) and FoxA2 as markers of lung development (A), myelocytomatosis oncogene (myc) and transforming growth factor-β (TGFβ) as markers of cell differentiation (B), surfactant proteins B and C (SP-B and SP-C) as markers of type II cells (C), and aquaporin 5 (Aqp5) and T1α as markers of type I cells (D) after intrapulmonary injection of C/EBPα siRNA into neonatal lung exposed to 72 h of hyperoxia (O2). Values are means ± SE of 3 mice. *P < 0.05 vs. control siRNA-injected group (Con) in 72-h air exposure (Air). †P < 0.05 vs. Con in O2. E: representative Western blots of protein levels of alveolar type II and type I cell markers, as well as proliferating cell nuclear antigen (PCNA), a general cell proliferation marker.