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. Author manuscript; available in PMC: 2012 Aug 10.
Published in final edited form as: Structure. 2011 Aug 10;19(8):1149–1159. doi: 10.1016/j.str.2011.05.011

Figure 7.

Figure 7

Molecular model of AMSH in complex with membrane associated CHMP3. AMSH can be recruited to membranes early in the ESCRT pathway via ESCRT-0 Stam. This might be independent of ESCRT-III CHMP3 interaction or both processes could be linked. If AMSH interacts with activated CHMP3 present in ESCRT-III polymers on membranes, the DUB activity could have an action radius of > 20 nm due to the long helical arm of AMSH and the flexible linkage of the CHMP3 MIM to the core of CHMP3 mediating ESCRT-III polymerization.