Skip to main content
. 2000 May 15;105(10):1345–1352. doi: 10.1172/JCI8635

Figure 1.

Figure 1

Targeted disruption of the mouse ADAMTS-1 gene. (a) Genomic locus, targeting vector, and predicted targeted locus. Black boxes represent exons 1–9. The probe for Southern analysis is indicated. B, BamHI; E, EcoRI; G, BglII. (b and c) Southern analysis of genomic DNA from targeted ES cells (b) and the offspring from a heterozygote intercross (c). The 7.0-kb EcoRI fragment and the 11.5-kb BamHI fragment denote the homologous recombinant allele. (d) RT-PCR of total RNA extracted from the kidney of each genotype. No ADAMTS-1 expression is detected in ADAMTS-1–/– mice.