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. 2011 May 6;301(2):H409–H417. doi: 10.1152/ajpheart.00084.2011

Fig. 2.

Fig. 2.

Contractile responses to Up4A in the presence of nitric oxide synthase (NOS) inhibitor are augmented in RA but not PA from DOCA-salt hypertensive rats. Concentration-response curves for Up4A in isolated rings of RA (A) or PA (B) in the presence of 10−4 M NG-nitro-l-arginine (l-NNA) are shown. C, D: contractile response to Up4A in the presence of NOS inhibitor is suppressed by purinergic (P2)Y antagonist but not by P2X antagonist in RA. Effects of 10−4 M suramin (C) or 10−4 M diinosine pentaphosphate pentasodium salt hydrate (Ip5I; D) on concentration-response curves for Up4A in RA obtained from DOCA-salt and Uni rats in the presence of 10−4 M l-NNA. Data are means ± SE from 3 to 8 experiments; the SE is included only when it exceeds the dimension of the symbol used. The concentration-response curves for Up4A depicted in A are replotted in C and D. *P < 0.05 vs. Uni l-NNA group; #P < 0.05 DOCA l-NNA vs. DOCA l-NNA suramin group; †P < 0.05, Uni l-NNA suramin vs. DOCA l-NNA suramin group.