Fig. 3.

Contractile responses to P2Y agonists in the presence of NOS inhibitor are augmented in RA from DOCA-salt hypertensive rats. Concentration-response curves for selective P2Y receptor agonist [2-thiouridine 5′-triphosphate tetrasodium salt (2-ThioUTP; P2Y₂ agonist; A), uridine-5′-(γ-thio)-triphosphate trisodium salt (UTPγS; P2Y₂/P2Y₄ agonist; B), and 5-iodouridine-5′-O-diphosphate trisodium salt (MRS 2693; P2Y₆ agonist; C)] in isolated rings of RA obtained from DOCA-salt and Uni rats in the presence of 10⁻⁴ M l-NNA are shown. Data are means ± SE from 4 or 5 experiments; the SE is included only when it exceeds the dimension of the symbol used. *P < 0.05, DOCA vs. Uni.