Table 1.
Optimized parameter values for 9 channel variants
| Value |
||||
|---|---|---|---|---|
| Optimized parameter | Description | Units | Mesenteric | Femoral |
| NSC with stress-controlled Ca2+ conductance (CaNSCσCC) | ||||
| ρCaNSCσCCmax | CaNSCσCC maximal ratio of σ-control to normal conductance | unitless | 5.628 | 14.610 |
| nCaNSCσCC | CaNSCσCC sensitivity to stress | unitless | 3.475 | 1.790 |
| σ50,CaNSCσCC | CaNSCσCC 1/2 activation stress | kPa | 82.690 | 76.746 |
| NSC with stress-controlled Na+ conductance (NaNSCσCC) | ||||
| ρNaNSCσCCmax | NaNSCσCC maximal ratio of σ-control to normal conductance | unitless | 6.997 | 7.931 |
| nNaNSCσCC | NaNSCσCC sensitivity to stress | unitless | 4.161 | 2.742 |
| σ50,NaNSCσCC | NaNSCσCC 1/2 activation stress | kPa | 82.245 | 34.107 |
| NSC with stress-controlled gating voltage (NSCσCC) | ||||
| VNaNSCσCCoff max | NSCsCC max offset of gating voltage | mV | 403.429 | 665.142 |
| nNSCσCC | NSCσCC sensitivity to stress | unitless | 2.299 | 1.136 |
| σ50,NSCσCC | NSCσCC 1/2 activation stress | kPa | 91.222 | 82.789 |
| Supp Ca2+ with stress-controlled conductance (CaσCC) | ||||
| GCaσCCmax | CaσCC maximal conductance | pA/mV | 2.365 | 3.926 |
| nCaσCC | CaσCC sensitivity to stress | unitless | 1.647 | 1.755 |
| σ50,CaσCC | CaσCC 1/2 activation stress | kPa | 1881.08 | 764.942 |
| Supp Na+ with stress-controlled conductance (NaσCC) | ||||
| gNaσCCmax | NaσCC maximal conductance | pA/mV | 4.272 | 5.139 |
| nNaσCC | NaσCC sensitivity to stress | unitless | 2.707 | 1.948 |
| σ50,NaσCC | NaσCC 1/2 activation stress | kPa | 300.937 | 211.178 |
| L-type Ca2+ with stress-controlled gating voltage (CaLσCC) | ||||
| VCaLσCCoff max | CaLσCC maximal membrane potential offset | mV | 32.490 | 71.636 |
| nCaLσCC | CaLσCC sensitivity to stress | unitless | 2.875 | 1.346 |
| σ50,CaσCC | CaLσCC 1/2 activation stress | kPa | 74.463 | 68.855 |
| L-type Ca2+ with stress-controlled conductance (ρCaLσCC) | ||||
| ρρCaLσCCmax | ρCaLσCC maximal ratio of σ-control to normal conductance | unitless | 7.134 | 20.000 |
| nρCaLσCC | ρCaLσCC sensitivity to stress | unitless | 3.194 | 1.535 |
| σ50,ρCaLσCC | ρCaLσCC 1/2 activation stress | kPa | 76.946 | 84.928 |
| BKCa with stress-controlled gating voltage (BKCaσCC) | ||||
| VBKCaσCCoff max | BKCaσCC maximal membrane potential offset | mV | 20.00 | 19.866 |
| nBKCaσCC | BKCaσCC sensitivity to stress | unitless | 2.000 | 2.504 |
| σ50,BKCaσCC | BKCaσCC 1/2 activation stress | kPa | 54.598 | 1010.50 |
| BKCa with stress-controlled conductance (ρBKCaσCC) | ||||
| ρρBKCaσCCmax | ρBKCaσCC maximal ratio of σ-control to normal conductance | unitless | 0.000 | 0.000 |
| nρBKCaσCC | ρBKCaσCC sensitivity to stress | unitless | 2.027 | 1.711 |
| σ50, ρBKCaσCC | ρBKCaσCC 1/2 activation stress | kPa | 49.620 | 1.648 |
Parameter values of optimized fits of integrated model to experimental data for vessel stress-controlled nonselective cation (NSC), supplementary Ca2+ (Supp Ca2+), supplementary Na+ (Supp Na2+), L-type Ca2+ and large-conductance, Ca2+-activated K+ (BKCa) channels. Parameter values for stress-controlled voltage gating of NSC and both stress-controlled voltage gating and conductance of BKCa produce inadequate fits to experimental data that were found to be independent of initial guess. The fit to femoral data of the model containing an L-type Ca2+ channel with stress-controlled conductance produces a ρCaNSCσCCmax at its upper bound of the optimization range. This is an example in which transient response data is critical to uniquely define a set of parameters from the large set of virtually equivalently fitting optimized parameter values.