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. 2000 May 15;105(10):1465–1472. doi: 10.1172/JCI9213

Figure 1.

Figure 1

Protection of male but not female BV8S2 Tg mice with BV8S2 protein. Littermate males (a and b) or females (c and d) were treated with saline/IFA or GST/IFA (controls) or 12.5 μg BV8S2 protein/IFA on days –7 and +3 relative to challenge with MBP-Ac1-11 peptide/CFA + pertussigen to induce EAE, with (b and d) or without (a and c) weekly boosting with 12.5 μg BV8S2 protein injected subcutaneously in saline. Note nearly complete protection against EAE in boosted males and delayed onset but eventual development of severe EAE in boosted females. Data from male mice are taken from ref. 19.