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. 2011 May 11;31(8):1778–1787. doi: 10.1038/jcbfm.2011.66

Figure 2.

Figure 2

Representative magnetic resonance imaging (MRI) maps and [14C]2-deoxyglucose (2-DG) autoradiograms from the rostral slice in a stroke rat. (A) T2* Oxygen challenge (OC) percentage signal change map. (B) Thresholded T2* OC map. (C) [14C]2-deoxyglucose autoradiogram. (D) Cerebral blood flow (CBF) map (mL per 100 g per minute). (E) Apparent diffusion coefficient (ADC) map ( × 10−3 mm2/s). (F) Diffusion-weighted imaging/perfusion-weighted imaging (DWI/PWI) overlay (mismatch tissue is shown in red). Regions of interest (ROIs) were defined as follows: Green ROI: penumbra—the thresholded region displaying the greatest T2* percentage signal change excluding veins and ventricles (B). Yellow ROI: hyperglycolytic region—identified by the dark band within the ipsilateral cortex on the 2-DG autoradiogram (C). Red ROI: ischemic core—within the ADC-derived lesion in the caudate nucleus (E). White ROI: contralateral cortex—homotopic to the penumbra ROI. Sky Blue ROI: contralateral caudate nucleus—homotopic to the ischemic core ROI.