Figure 1.

(a) The effect of chronic administration of low-dose aspirin (ASA; 81 mg for 10 days) and acute administration of the nonselective NSAID ibuprofen (800 mg) on the pyrexial response to 4 ng/kg LPS. Ibuprofen, but not aspirin, significantly attenuated the pyrexial response to endotoxin (P < 0.01). (b) The effect of LPS on heart rate is not altered by either aspirin or ibuprofen (^AP = NS). (c) Pretreatment with either celecoxib (800 mg) or ibuprofen (800 mg) significantly (P < 0.01) depressed the pyrexial response to LPS (4 ng/kg). Body temperature did not differ significantly between subjects receiving celecoxib or ibuprofen before LPS. NS, not significant.