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. 2000 May 15;105(10):1473–1482. doi: 10.1172/JCI9523

Figure 3.

Figure 3

(a) The effect of LPS on Tx-M excretion with selective COX-1 and nonselective COX inhibition. Inhibition of platelet COX-1 with low-dose aspirin partially inhibits excretion of TX-M evoked by 4 ng/kg LPS. By contrast, ibuprofen completely inhibits the increase in thromboxane biosynthesis induced by the endotoxin (P < 0.01). (b) The effect of LPS on PGI-M excretion after selective and nonselective COX inhibition. The increment in PGI-M excretion evoked by 4 ng/kg LPS is partially inhibited by low-dose aspirin. Nonselective inhibition of both COX isoforms completely inhibits PGI-M excretion. (c) The effect of LPS on PGI-M excretion after selective and nonselective COX inhibition. Although celecoxib substantially depressed the increment in PGI-M, it is depressed further by ibuprofen. AP < 0.05; BP < 0.001.