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. 2011 Jun 8;31(23):8491–8501. doi: 10.1523/JNEUROSCI.5317-10.2011

Figure 3.

Figure 3.

Development-dependent expression of NRG1 types. RT-qPCR was performed as described in Figure 1A with the RNA templates of cerebral cortex of different age. A, Different expression levels of NRG1 types in E18 cerebral cortex. The copy numbers per microgram of total RNA of each type of NRG1 were 6.81 ± 0.09 × 105 (type I), 1.28 ± 0.06 × 106 (type II), 7.81 ± 0.17 × 105 (type III), 557 ± 127 (type IV), 3890 ± 850 (type V), and 31 ± 14 (type VI), whereas that for total NRG1 was 2.75 ± 0.08 × 106. B, Composition of NRG1 types in E18 cerebral cortex. C, Different expression levels of NRG1 types in P5 cerebral cortex. The copy numbers per microgram of total RNA of each type NRG1 were 3.22 ± 0.10 × 106 (type I), 9.16 ± 0.45 × 106 (type II), 6.03 ± 0.40 × 106 (type III), 1.43 ± 0.12 × 103 (type IV), 2.79 ± 0.50 × 106 (type V), and 1.06 ± 0.63 × 103 (type VI), whereas that for total NRG1 was 2.12 ± 0.12 × 107. D, Composition of NRG1 types in P5 cerebral cortex. E, Different expression levels of NRG1 types in P15 cerebral cortex. The copy numbers per microgram of total RNA of each type NRG1 were 4.51 ± 0.75 × 104 (type I), 6.25 ± 0.33 × 105 (type II), 2.35 ± 0.06 × 105 (type III), 0 (undetectable, type IV), 1.02 ± 0.08 × 104 (type V), and 3.26 ± 2.32 × 102 type VI, whereas that for total NRG1 was 9.16 ± 0.27 × 107. F, Composition of NRG1 types in P15 cerebral cortex. G, Different expression levels of NRG1 types in P70 cerebral cortex. The copy numbers per microgram of total RNA of each type NRG1 were 1.46 ± 0.21 × 104 (type I), 1.46 ± 0.28 × 105 (type II), 1.88 ± 0.25 × 105 (type III), 0 (undetectable, type IV), 5.58 ± 13.60 × 102 (type V), and 64 ± 13 (type IV), whereas that for total NRG1 was 3.54 ± 0.55 × 107. H, Composition of NRG1 types in P70 cerebral cortex. I, Alteration of NRG1 types in developing cerebral cortex.