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Urinary ET-1 excretion is blunted in Dahl salt-sensitive (Dahl S) rats in response to high Na+ intake. When Dahl salt-resistant (Dahl R; n = 6) rats are placed on a high-salt (HS) diet, urinary endothelin-1 (ET-1) increases six-fold; however, the increase in urinary ET-1 excretion was significantly attenuated in Dahl S. *Significant difference, P < 0.05 vs. all other groups.
