Table 6.
Recipients with ACR
| Pt | Graft failed | # ACR | <borderline | 1a | 1b | 2a | 2b | 3 | AMR | Days to 1st ACR | Prewean vs. postwean ACR | Wean time | Treatment of ACR | A MM | B MM | DR MM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1 | No | 1 | 1 | 1 | 0 | 0 | 0 | 112 | Prewean ACR at 112 days | Solu | 2 | 1 | 2 | |||
| #2 | No | 2 | 1 | 1 | 0 | 0 | 0 | 142 | Prewean ACR at 142 days | Solu/solu | 1 | 2 | 1 | |||
| #3 | No | 1 | 0 | 0 | 1 | 0 | 0 | 17 | Prewean ACR at 17 days | Thymo | 0 | 1 | 1 | |||
| #4 | No | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 62 | Prewean ACR at 62 days | None | 0 | 1 | 1 | ||
| #5 | No | 1* | 1 | 1 | 1 | 0 | 0 | 335 | Postwean ACR at 179 days | 156 | Solu/solu/solu | 0 | 1 | 1 | ||
| #6 | No | 1 | 0 | 1 | 0 | 0 | 0 | 356 | Prewean ACR at 356 days | None | 2 | 2 | 1 | |||
| #7 | No | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 541 | Postwean ACR at 211 days | 330 | Solu | 1 | 2 | 2 | |
| #8 | No | 2 | 1 | 0 | 0 | 0 | 0 | C4d+,DSA+ | 8 | Prewean ACR at 8 days | Solu/PP + IVIg | 1 | 1 | 1 | ||
| #9 | No | 2 | 1 | 1 | 0 | 0 | 0 | 220 | Prewean ACR at 220 days | Solu/solu | 1 | 2 | 2 | |||
| #10 | No | 1 | 0 | 0 | 1 | 0 | 0 | 541 | Postwean ACR at 283 days | 258 | Campath | 1 | 1 | 1 | ||
| #11 | No | 2 | 1 | 1 | 0 | 0 | 0 | 680 | Postwean ACR at 422 days | 258 | Solu | 1 | 2 | 2 | ||
| #12 | Yes, +BK virus | 2 | 1 | 1 | 0 | 0 | 0 | 303 | Postwean ACR at 175 days | 128 | Solu/IVIg | 2 | 2 | 2 | ||
| #13 | No | 2 | 1 | 1 | 0 | 0 | 0 | 435 | Prewean ACR at 435 days | Campath/solu | 2 | 2 | 1 | |||
| #14 | No | 1 | 1 | 0 | 0 | 0 | 0 | 18 | Prewean ACR at 18 days | Solu/solu | 1 | 1 | 1 | |||
| #15 | No | 2 | 1 | 1 | 0 | 0 | 0 | 387 | Postwean ACR at 171 days | 216 | Campath | 1 | 1 | 1 | ||
| #16 | No | 2 | 1 | 1 | 0 | 0 | 0 | 399 | Postwean ACR at 206 days | 193 | Solu/solu | 1 | 1 | 1 | ||
| #17 | Yes | 1 | 1 | 0 | 0 | 0 | 0 | 255 | Postwean ACR at 60 days | 195 | Solu | 1 | 1 | 1 | ||
| #18 | No | 2 | 0 | 1 | 1 | 0 | 0 | 345 | Postwean ACR at 138 days | 207 | Campath/solu | 0 | 1 | 2 | ||
| #19 | Yes | 1 | 1 | 0 | 0 | 0 | 0 | 478 | Postwean ACR at 289 days | 189 | Solu | 1 | 1 | 1 | ||
| #20 | No | 1 | 0 | 1 | 0 | 0 | 0 | 577 | Postwean ACR at 318 days | 259 | Campath | 1 | 0 | 1 | ||
| #21 | Yes | 2 | 1 | 0 | 0 | 1 | 0 | 282 | Postwean ACR at 93 days | 189 | Solu/campath | 2 | 2 | 2 | ||
| #22 | *&astYes, no immuno | 1 | 0 | 0 | 0 | 0 | 1 | 195 | Postwean ACR at 82 days | 113 | None, esophageal perf | 2 | 2 | 2 |
Pt = recipients.
ACR = number of episodes of acute cellular rejections (Banff 1a, 1b, 2a, 2b and 3 classification).
Days to 1 st ACR = days to 1 st episode of ACR.
Prewean vs. postwean ACR = 1st episode of preweaning (from posttransplant days) vs. postweaning ACR (days after weaning occurs).
Wean time = days to wean tacrolimus monotherapy from a consolidated daily dosing to less than that (e.g. qd to qod/3×/week).
AMR = antibody-mediated rejection with evidence of +C4d and +DSA (donor specific antibody). Pt underwent plasmapheresis + IVIg
MM = HLA mismatch at the A, B and DR loci.
Solu = solumedrol pulse.
Thymo = thymoglobulin.
pp = plasmapheresis.
Campath = 30 mg IV×1.
1 = one continuous episode of ACR from 2a to 1b to 1a and resolution with solumedrol.
Yes, no immuno = Pt died from sepsis secondary to an esophageal perforation from an EGD with immunosuppression withdrawn and resultant loss of allograft from ACR.