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. Author manuscript; available in PMC: 2011 Aug 11.
Published in final edited form as: Transplantation. 1994 Mar 27;57(6):918–922. doi: 10.1097/00007890-199403270-00025

TABLE 1. Survival of hamster heart xenografts in liver xenograft recipients injected with active or decomplemented rat antihamster hyperimmune serum.

Heart recipients (immunosuppression) Transferred hyperimmune serum
Active (MST±SD) Inactive (MST±SD)
1. Normal LEWa (none) 2,2,2,3,3 min (2.4±0.5) 8,10,15,18,32 min (16.6±9.4)
2. LEW rat (CyP 8 mg/kg/day × 10 + FK506 1 mg/kg/day × 30)b 2,2,3,3,4 min (2.8±0.8) 6,12,12,21,28 min (15.8±8.6)
3. OLT ratc,d (CyP + FK506) 7,8,12,16,32 min (15.1±10.1) 23,23,25,27,28 days (25.2±2.2)
a

LEW rat recipients normally reject hamster hearts in a mean of 3.0 days (1).

b

Pretreatment (This kind of pretreatment normally extends survival of hamster hearts beyond 3 days).

c

LEW rats that received a hamster liver transplant 40–60 days before and were immunosuppressed with CyP and FK506 as in group 2 for 30 days, with no treatment thereafter. The preexisting liver xenografts were not adversely affected at the time of heart rejection using inactivated HS. With active HS, the liver of 4 of 5 rats underwent humoral rejection in less than 24 hr, the fifth rat survived another 50 days.

d

When unaltered (n=5) or decomplemented (n=5) normal rat serum was given instead of HS, heart xenograft survival was unaffected in group 1 (3 days), and in group 3 (25 days).