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. 2011 May 25;106(2):817–827. doi: 10.1152/jn.00578.2010

Fig. 7.

Fig. 7.

Increased synaptic GABA by elimination of the GABA (reuptake) transporter SNF-11 or by concomitantly photoevoked GABA release alters ACh-evoked body contractions. Body contractions (means ± SE) were evoked by 30-s continuous (indicated by blue bar in A) or by 2-Hz, 10-ms pulsed 1.4 mW/mm2 photostimulation (indicated by blue tick marks in B) of wild-type, snf-11(ok156), and snf-11(ok156); gbb-2(tm1165) animals carrying transgene zxIs6 (ACh). ANOVA for the first 8.5 s of the light stimulus showed significant differences between the wild type and the 2 mutant strains, as well as between mutants. C: wild-type animals expressing ChR2 in cholinergic neurons only (zxIs6) or in both cholinergic and GABAergic neurons (zxIs3; zxIs6) were exposed to a constant light stimulus (indicated by shaded bar), and body contractions were quantified. Values are means ± SE; n = no. of animals tested. ANOVA was performed from −2 to 6 s relative to the light stimulus. ***P < 0.001.