Fig. 2.

Dependence of optimal control on maximum current bound, I_max. First, third, and fifth rows: optimized current injections for I_max = 12, 8, and 4 nA, respectively (all other model and cost parameters and attributes were fixed in all three cases and were the same as those used in Fig. 1). Dashed lines show upper and lower current bounds, ±I_max. Second, fourth, and sixth rows: target spike trains at top (in gray) and rasters of 20 trial responses to test the reliability of the resulting spike train given the optimal currents for those values of I_max. As expected, imposing more restrictive constraints on the current reduces the accuracy of the spike trains elicited by injecting the optimal current.