Fig. 1.

Streptozotocin (STZ)-treated mice develop diabetes, weight loss, and sensory hypoalgesia over the course of 8 wk. A: average blood glucose level of diabetic (STZ-injected) and nondiabetic (vehicle-injected) mice. B: average weight of diabetic and nondiabetic mice. C: behavioral mechanical response threshold (von Frey filament applied to the plantar hindpaw). D: behavioral thermal response latency (stimulus applied to the plantar hindpaw). **P < 0.01 by Student's t-test; ††P < 0.01 by Wilcoxon rank-sum test.