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Diabetes increases heat response thresholds in C-fibers. A: proportion of C-fibers sensitive to heat. B: numbers of APs elicited by heat ramp (32 to 52°C over 10 s). C: heat response threshold. D: proportion of C-fibers sensitive to 1 μM capsaicin. E: numbers of APs elicited by 1 μM capsaicin. †P < 0.05 by a Wilcoxon rank-sum test.
