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. 2011 May 18;106(2):801–808. doi: 10.1152/jn.00575.2010

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Fig. 4. — DRN neurons express functional nicotinic acetylcholine receptors (nAChRs). A: focal application of 1 mM ACh (arrows) induced rapid inward currents in 60.7% of DRN neurons tested (n = 84, black traces). In a subset of responsive neurons, pretreatment with 10 nM methyllycaconitine (MLA) inhibited ACh-induced currents (gray trace). B: in a subset of responsive neurons, pretreatment with 1 μM dihydro-β-erythroidine (DHβE) inhibited ACh-induced currents (gray trace). C: pretreatment of the slice with 100 μM mecamylamine (MEC, dark gray trace) blocked the ACh-induced current (black trace), but 1 μM prazosin (Praz, light gray trace) had no effect. D: average ACh-induced current in the presence of the antagonists tested as % of control. Bars represent means ± SE. Filled circles represent individual current amplitudes. Scale: A and B, 50 pA and 1 s; C: 200 pA, 0.5 s.