Fig. 6.
Nicotine induces weak modulation of inhibitory inputs to DRN neurons. A: example frequency histogram demonstrating increased spontaneous inhibitory postsynaptic current (sIPSC) frequency after application of 1 μM nicotine. Inset: representative traces before (Control) and after perfusion with nicotine. Scale: 25 pA, 25 ms. B: effect of 1 μM nicotine application on sIPSC frequency in DRN neurons. Responsive cells were identified by comparing sIPSC frequency before and during nicotine application (see materials and methods). Nicotine increased sIPSC frequency in 16.7% of cells tested and decreased sIPSC frequency in 16.7% of cells tested. Bars represent means ± SE. Filled circles represent individual observations.